Publications

Full publication list: https://scholar.google.com/citations?hl=en&user=3no8Uy8AAAAJ

(*=corresponding authors)

Yu, H.*, Xu, S., Jangir, Y., Wegener, G., Orphan, V.J.*, and El-Naggar, M.Y.* (2025) Redox conduction facilitates direct interspecies electron transport in anaerobic methanotrophic consortia. Science Advances. eadw4289. https://doi.org/10.1126/sciadv.adw4289

Lyu, X., Yu, H.*, and Lu, Y.* (2025) Diversity and function of soluble heterodisulfide reductases in methane-metabolizing archaea. Microbiology Spectrum. 13(5) e03238-24. https://doi.org/10.1128/spectrum.03238-24

Rodríguez, O., Metcalfe, K.S., McGlynn, S.E., Yu, H., Dekas, A.E., Ellisman, M., Deerinck, T., Grotzinger, J.P., and Orphan, V.J. (2023) Microbially-induced precipitation of silica by anaerobic methane-oxidizing consortia and implications for microbial fossil preservation. Proceedings of the National Academy of Sciences of the United States of America, 120 (51) e2302156120. https://doi.org/10.1073/pnas.2302156120

Murali, R., Yu, H., Speth, D.R., Wu, F., Metcalfe, K. S., Crémière, A., Laso-Pèrez, R., Malmstrom, R.R., Goudeau, D., Woyke, T., Hatzenpichler, R., Chadwick, G.L., Connon, S.A., and Orphan, V.J. (2023). Physiological potential and evolutionary trajectories of syntrophic sulfate-reducing bacterial partners of anaerobic methanotrophic archaea. PLoS Biology, 21(9), e3002292. https://doi.org/10.1371/journal.pbio.3002292

Yu, H.*, Speth, D.R., Connon, S.A., Goudeau, D., Malmstrom, R.R., Woyke, T., and Orphan, V.J.* (2022) Community structure and microbial associations in sediment-free methanotrophic enrichment cultures from a marine methane seep. Applied and Environmental Microbiology. e02109-21. https://doi.org/10.1128/aem.02109-21

Heryakusuma, C., Susanti, D., Yu, H., Li, Z., Purwantini, E., Hettich, R.L., Orphan, V.J., and Mukhopadhyay, B. (2022) A reduced F420-dependent nitrite reductase (FNiR) in an anaerobic methanotrophic archaeon. Journal of Bacteriology. e00078-22. https://doi.org/10.1128/jb.00078-22

Yu, H.*, Chadwick, G.L., Lingappa, U.F., and Leadbetter J.R.* (2022) Comparative genomics on cultivated and uncultivated, freshwater and marine “Candidatus Manganitrophaceae” species implies their worldwide reach in manganese chemolithoautotrophy. mBio. 13 (2), e03421-21. https://doi.org/10.1128/mbio.03421-21

Chadwick, G. L., Skennerton, C. T., Laso-Pérez, R., Leu, A. O., Speth, D. R., Yu, H., Morgan-Lang, C., Hatzenpichler, R., Goudeau, D., & Malmstrom, R. (2022). Comparative genomics reveals electron transfer and syntrophic mechanisms differentiating methanotrophic and methanogenic archaea. PLoS Biology 20 (1): e3001508. https://doi.org/10.1371/journal.pbio.3001508

Yu, H., Skennerton, C.T., Chadwick, G.L., Leu, A.O., Aoki, M., Tyson, G.W., and Orphan V.J. (2022) Sulfate differentially stimulates but is not respired by diverse anaerobic methanotrophic archaea. The ISME Journal 16, 168–177. https://doi.org/10.1038/s41396-021-01047-0 (Editors’ Choice)

Yu, H., Leadbetter, J.R. (2020) Bacterial chemolithoautotrophy via manganese oxidation. Nature 583, 453–458. https://doi.org/10.1038/s41586-020-2468-5 (Nature Cover)

Yu, H., Susanti, D., McGlynn, S.E., Skennerton, C.T., Chourey, K., Iyer, R., Scheller, S., Tavormina, P., Hettich, R.L., Mukhopadhyay, B., and Orphan, V.J. (2018) Comparative genomics and proteomic analysis of assimilatory sulfate reduction pathways in anaerobic methanotrophic archaea. Frontiers in Microbiology. 9. https://doi.org/10.3389/fmicb.2018.02917

Scheller, S., Yu, H., Chadwick, G.L., McGlynn, S.E., and Orphan, V.J. (2016) Artificial electron acceptors decouple archaeal methane oxidation from sulfate reduction. Science 351: 703–707. https://doi.org/10.1126/science.aad7154 (Science Perspective)

van Baren, M.J., Bachy, C., Reistetter, E.N., Purvine, S.O., Grimwood, J., Sudek, S., Yu, H., Poirier, C., Deerinck, T.J., Kuo, A., Grigoriev, I.V., Wong, C., Smith, R.D., Callister, S.J., Wei, C., Schmutz, J., and Worden, A.Z. (2016) Evidence-based green algal genomics reveals marine diversity and ancestral characteristics of land plants. BMC Genomics 17: 267. https://doi.org/10.1186/s12864-016-2585-6

Glass, J.B., Yu, H., Steele, J.A., Dawson, K.S., Sun, S., Chourey, K., Pan, C., Hettich, R.L., Orphan, V.J. (2014) Geochemical, metagenomic and metaproteomic insights into trace metal utilization by methane-oxidizing microbial consortia in sulphidic marine sediments. Environmental Microbiology 6, 1592-1611. https://doi.org/10.1111/1462-2920.12314

Hartmann, M., Howes, C.G., VanInsberghe, D., Yu, H., Bachar, D., Christen, R., Nilsson, R.H., Hallam, S.J. and Mohn, W.W. (2012) Significant and persistent impact of timber harvesting on soil microbial communities in Northern coniferous forests. The ISME Journal 6, 2199–2218. https://doi.org/10.1038/ismej.2012.84

Patents

Scheller, S., Orphan, V. J. and Yu, H. (2017). Methane oxidation methods and compositions. United States Patent No. US20170107479A1.