張照斌

本人主要研究環(huán)境污染對(duì)人體健康和生態(tài)的影響，即采用現(xiàn)代生物學(xué)技術(shù)、化學(xué)分析技術(shù)和分子模擬等技術(shù)手段，發(fā)掘新型有毒有害環(huán)境污染物、解析環(huán)境污染物的毒性與危害并闡明其毒理機(jī)制。研究方向包括環(huán)境健康、環(huán)境毒理、生態(tài)毒理，擅長(zhǎng)分子機(jī)制、受體活性、高通量測(cè)序分析。

2005.6北京大學(xué)環(huán)境學(xué)院環(huán)境地理學(xué)專業(yè)博士研究生畢業(yè)。

2010.11-2011.8 在美國(guó)明尼蘇達(dá)大學(xué)做訪問(wèn)學(xué)者
2009.8- 今 北京大學(xué)城市與環(huán)境學(xué)院副教授
2007.7-2009.7 北京大學(xué)城市與環(huán)境學(xué)院講師
2005.9-10月日本大阪大學(xué)作短期學(xué)習(xí)訪問(wèn)
2005.7-2007.6 北京大學(xué)環(huán)境學(xué)院環(huán)境科學(xué)與工程專業(yè)博士后

環(huán)境毒理學(xué)和生態(tài)毒理學(xué)

環(huán)境毒理學(xué)和生態(tài)毒理學(xué)

國(guó)家自然科學(xué)獎(jiǎng)，2015.

唐立新獎(jiǎng)教金教學(xué)名師獎(jiǎng)，2017.

北京大學(xué)優(yōu)秀班主任，2018 .

1. 國(guó)家自然科學(xué)基金(20607002) 雌激素相關(guān)受體介導(dǎo)的環(huán)境內(nèi)分泌干擾物質(zhì)的信號(hào)通道研究 2007（結(jié)題）.負(fù)責(zé)
2. 國(guó)家自然科學(xué)基金(20877003) 雌激素相關(guān)受體介導(dǎo)的環(huán)境內(nèi)分泌干擾物質(zhì)的信號(hào)通道研究 2009-2011.負(fù)責(zé)
3. 國(guó)家自然科學(xué)基金(20837003) 環(huán)境中PPCPs 的遷移轉(zhuǎn)化、生態(tài)健康風(fēng)險(xiǎn)及控制原理 2009-2012.專題負(fù)責(zé)
4. 國(guó)家自然科學(xué)基金委重點(diǎn)項(xiàng)目(40632009) 遼東灣中內(nèi)分泌干擾物質(zhì)的風(fēng)險(xiǎn)評(píng)價(jià) 2007-2009.參加
5. 國(guó)家科技部“973”計(jì)劃項(xiàng)目(2007CB407304) 京津渤區(qū)域復(fù)合污染過(guò)程、生態(tài)毒理效應(yīng)及控制修復(fù)原理 2007-2011.參加

6.國(guó)家自然科學(xué)基金面上項(xiàng)目(21377007)，抗雌激素活性含芴化合物的魚(yú)類繁殖發(fā)育毒性及毒理機(jī)制研究，2014.1-2017.12.負(fù)責(zé)

7.國(guó)家自然科學(xué)基金委重點(diǎn)項(xiàng)目(41330637)：富營(yíng)養(yǎng)化水體中新型內(nèi)分泌干擾物質(zhì)的污染特征和復(fù)合生態(tài)毒理效應(yīng)；執(zhí)行時(shí)間：2014-2018。參加

8. 政府間國(guó)際科技創(chuàng)新合作重點(diǎn)專項(xiàng)（2016YFE0117800）；2016.12-2019.12.參加

9.國(guó) 家自然科學(xué)基金面上項(xiàng)目(21777003)，尼伯金酯誘發(fā)小鼠卵巢囊腫的毒理學(xué)研究，2018.01-2021.12.負(fù)責(zé)

10.國(guó)家重點(diǎn)研發(fā)計(jì)劃課題（2017YFF0211202）；化學(xué)品內(nèi)分泌干擾活性高通量及高內(nèi)涵快速篩查與確證技術(shù)研究，2017.07 -2020.12.負(fù)責(zé)

發(fā)表期刊論文：

Zhang, Zhaobin; Hu, Ying; Guo, Jilong; Yu, Tong; Sun, Libei; Xiao, Xuan; et al., Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice. Nature Communications. 8(14585):1-13; 2017.（highlighted，該文被Natureasia、Newscientist等國(guó)內(nèi)外數(shù)百家媒體專題報(bào)道）

Libei Sun, Tong Yu, Jilong Guo, Zhaobin Zhang, Ying Hu, Xuan Xiao, Yingli Sun, Han Xiao, Junyu Li, Desheng Zhu, Linlin Sai & Jun Li; 2016. The estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats. Scientific Reports. 6(25173):1-9.

http://pku.cuepa.cn/show_more.php?tkey=&bkey=&doc_id=2201108；http://news.sciencenet.cn/htmlnews/2017/3/370840.shtm；http://health.people.com.cn/n1/2017/0301/c14739-29114941.html ...

Yuyin Zhou, Mo Chen, Fanrong Zhao, Di Mu, Zhaobin Zhang, Jianying Hu, 2015. Ubiquitous Occurrence of Chlorinated Byproducts of Bisphenol A and Nonylphenol in Bleached Food Contacting Papers and Their Implications for Human Exposure. Environ. Sci. Technol., 49: 7218-7226.

Hong Zhang, Zhaobin Zhang, Tsuyoshi Nakanishi, Yi Wan, Youhei Hiromori, Hisamistu Nagase, Jianying Hu, 2015. Structure-Dependent Activity of Phthalate Esters and Phthalate Monoesters Binding to Human Constitutive Androstane Receptor. Chemical Research in Toxicology. 28(6): 1196-1204.

Fujun Ma, Zhaobin Zhang, Jialiong Jiang, and Jianying Hu. 2015. Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk. CHEMOSPHERE. 139: 256-259.

Adam T. Zarth, Guang Cheng, Zhaobin Zhang, Mingyao Wang, Peter W. Villalta, Silvia Balbo, Stephen S. Hecht, 2014. Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: Application to DNA from exposed mice and humans. Chemico-Biological Interactions. 215: 40-45.

Zhaobin Zhang, Libei Sun, Ying Hu, Jian Jiao, Jianying Hu, 2013. Inverse antagonist activities of parabens on human oestrogen-related receptor γ(ERRγ): In vitro and in silico studies. Toxicology and Applied Pharmacology 270:16–22.
Ying Hu, Zhaobin Zhang, Libei Sun, Jian Jiao, Desheng Zhu, Jun Li, Mingwen Qi, 2013. The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in SD rats. Food and Chemical Toxicology 53:69–74.
Zhang ZB, Jia CX, Hu Y, Sun LB, Jiao J, Li RB, Zhao L, Zhu DS, Li J, Tian YL, Bai HC, Hu JY, 2012. The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. Toxicology Letters. 209: 146-153.
Zhang ZB, Hu Y, Zhao L, Li J, Bai HC, Zhu DS, Hu JY, 2011. Estrogen agonist/antagonist properties of dibenzyl phthalate (DBzP) based on in vitro and in vivo assays. Toxicology Letters. 207: 7– 11.
Huang C, Zhang ZB, Wu SM, Zhao YB, Hu JY. 2010. In vitro and in vivo estrogenic effects of 17α-estadiol in medaka (Oryzias latipes). Chemosphere. 8(5): 608-612.
Hu JY, Zhang ZB, Wei QW, Zhen HJ, Zhao YB, Peng H, Wan Y, Giesy JP, Li LX, Zhang B. 2009. Malformations of the endangered Chinese sturgeon, Acipenser sinensis, and its causal agent. 6. Proceedings of the National Academy of Sciences of the United States of America, 106: 9339-9344. （highlighted，該文被Science網(wǎng)絡(luò)新聞和路透社等上百家國(guó)際媒體專題報(bào)道）
Zhang ZB, Hu JY, 2008. Effects of p,p `-DDE exposure on gonadal development and gene expression in Japanese medaka (Oryzias latipes). Journal of Environmental Sciences-China, 20(3): 347-352.
Zhang ZB, Hu JY, Zhen HJ, Wu XQ, Huang C, 2008. Reproductive inhibition and transgenerational toxicity of triphenyltin on medaka (Oryzias latipes) at environmentally relevant levels. 9. Environmental Science & Technology, 42 (21), 8133-8139. （該文研究結(jié)果受到Science網(wǎng)絡(luò)新聞報(bào)道引用）
Zhang ZB, Hu JY. 2007. Development and validation of endogenous reference genes for expression profiling of medaka（Oryzias latipes）exposed EDCs by quantitative real-time RT-PCR. Toxicological Sciences, 95: 356-368.
Zhang ZB, Hu JY, An W, Jin F, An LH, Tao S, Chen JS. 2005. Induction of vitellogenin mRNA in juvenile chinese sturgeon (Acipenser sinensis Gray) treated with 17beta-Estradiol and 4-Nonylphenol. Environmental Toxicology and Chemistry, 24 (8): 1944-1950.(該文曾被國(guó)際毒理化學(xué)學(xué)會(huì) (SETAC)網(wǎng)站以“全球內(nèi)分泌干擾物質(zhì)研究領(lǐng)域的2個(gè)發(fā)現(xiàn)”為題進(jìn)行專門介紹).
An LH, Hu JY, Zhang ZB, Yang M. 2006. Quantitative PCR analysis of vitellogenin mRNA in so-iny mullet, Chelon haematocheilus, from Bo Sea, north of China. Analytical and Bioanalytical Chemistry, 1995-2001.
WanY, Hu JY, An W, Zhang ZB, An LH, Tatsuya Hattori, Mitsuaki Itoh, and Shigeki Masunaga. 2006. Congener-specific tissue distribution and hepatic sequestration of PCDD/Fs in wild herring gulls from Bohai Bay, North China: comparison to coplanar PCBs. Environmental Science & Technology, 40(5): 1462-1468.
Wan Y, Wei QW, Hu JY, Jin XH, Zhang ZB, Zhen H J, Liu J Y. 2007. Levels, tissue distribution, and age-related accumulation of synthetic musk fragrances in Chinese sturgeon (Acipenser sinensis): Comparison to organochlorines. Environmental Science & Technology, 41 (2): 424-430.
An LH, Hu J Y, Zhu XY, Deng BS, Zhang ZB, Yang M, 2007. Crucian carp (Carassius carassius) VTG monoclonal antibody: Development and application. Ecotoxicology and Environmental Safety, 66 (2): 148-153.
An W, Hu JY, Wan Y, An LH, Zhang ZB. 2006. Deriving Site-Specific?2,2-Bis（chlorophenyl）-1,1- dichloroethylene quality criteria?of water and sediment for protection of common tern populations in Bohai Bay, North China. Environmental Science & Technology, 40 (8): 2511-2516.

賈成霞,張照斌,張清靖,劉盼,朱華,2012. 虹鱒魚(yú)PPARα基因克隆、序列分析及其組織表達(dá)分布.中國(guó)水產(chǎn)科學(xué).19(4): 707-714.

焦健, 張照斌, 胡建英, 王金水. 2010. hVDR原核表達(dá)及其與重金屬鎘、鉛的結(jié)合活性. 環(huán)境科學(xué). 31(10):2469-2473.

侯彥峰, 張照斌, 胡建英. 2009. 皮質(zhì)醇影響青鳉鰓內(nèi)鈉鉀ATP酶基因表達(dá)的研究. 生態(tài)毒理學(xué)報(bào). 4(2): 212-217.

張照斌, 胡建英, 賽思翔, 趙硯彬, 黃崇. 2008. 青鳉魚(yú)ERRα的克隆、序列分析、組織表達(dá)及其對(duì)不同EDCs暴露的響應(yīng). 環(huán)境科學(xué), 29, 3153-3158. (EI收錄)

王琪, 黃崇, 張照斌, 胡建英, 張仁陟. 2008. 實(shí)時(shí)定量RT-PCR方法檢測(cè)雌二醇誘導(dǎo)原代培養(yǎng)青鳉魚(yú)肝細(xì)胞的基因表達(dá). 環(huán)境科學(xué)學(xué)報(bào), 12, 2568-2572.

施嘉琛, 胡建英, 常紅, 萬(wàn)祎, 張照斌, 相艷. 2008. 北京溫榆河流域耐藥大腸桿菌的調(diào)查研究. 中國(guó)環(huán)境科學(xué), 28, 39-42. (EI收錄)

賽霖林, 張照斌, 胡建英, 侯彥峰, 賽道建. 2006. 評(píng)價(jià)內(nèi)分泌干擾物質(zhì)壬基酚雌激素活性的方法-定量PCR監(jiān)測(cè)卵黃蛋白原基因表達(dá). 環(huán)境科學(xué), 27, 1825-1828. (EI收錄)
侯彥峰, 張照斌, 胡建英, 范光麗. 2006. 雌激素誘導(dǎo)下的卵黃蛋白原基因表達(dá)與雌雄同體. 中國(guó)環(huán)境科學(xué), 26, 599-602. (EI收錄)
張照斌, 牛翠娟, 朱華, 胡紅霞. 2003. 室內(nèi)飼育西伯利亞鱘的血清性類固醇激素的周年變化. 北京師范大學(xué)學(xué)報(bào)(自然科學(xué)版), 39, 519-524.

會(huì)議論文
Zhang ZB, Hu JY. 2004. Oral presentation: Quantification of juvenile chinese sturgeon VTG mRNA levels using real-time RT-PCR after in vivo treatment with E2 and 4-NP, International Symposium on Biotechnology for Environmental Pollution Control, Beijing, China.
Zhang ZB, Hu JY. 2004. Poster presentation: Induction of vitellogenin genes in Juvenile Chinese Sturgeon (Acipenser sinensis Gray) after in vivo Treatment with EDCs. China-Japan Joint Symposium on Environmental Chemistry, Beijing, China.
Zhang ZB, Hu JY, Hou YF, Sai LL. 2005. Platform oral presentation: Gene expression in gonad of medaka exposed to EDCs and new markers for assessing EDCs. SETAC North America 26th Annual Meeting. Baltimore, MD, USA.
Hu JY, Zhang ZB, Sai LL, Hou YF. 2005. Post presentation: Gene expression in medaka embryo and fry exposed to EDCs and new program for monitoring. SETAC North America 26th Annual Meeting. Baltimore, MD, USA.
Zhang ZB, Hu JY, Zhen HJ, 2008. Platform oral presentation: Inhibition of reproduction and malformation of offspring in medaka by triphenyltin exposure at environmentally relevant levels. 5th SETAC World Congress. Sydney, Australia.

授權(quán)發(fā)明專利
張照斌. 雙酚芴及其衍生物在制備防治癌癥藥物中的應(yīng)用. 授權(quán)日期：2014.02.19. 專利號(hào)：201110093462.9.

張照斌、胡建英、安偉. 魚(yú)類單卵或魚(yú)苗的RNA和DNA同步提取及魚(yú)卵和幼魚(yú)的性別鑒定方法. 專利號(hào)：ZL 200510011322.7.

獲獎(jiǎng)情況

第三完成人獲國(guó)家自然科學(xué)二等獎(jiǎng)，典型內(nèi)分泌干擾物質(zhì)的環(huán)境行為和生態(tài)毒理效應(yīng)，獲獎(jiǎng)時(shí)間：2015.12.16.

執(zhí)教課程
環(huán)境生物學(xué)（本）, 講課和實(shí)驗(yàn) , 北京大學(xué) , 春季學(xué)期

環(huán)境毒理學(xué)（本）, 講課和實(shí)驗(yàn) , 北京大學(xué) , 春季學(xué)期
環(huán)境污染與人體健康（本）, 講課 , 北京大學(xué) , 秋季學(xué)期
環(huán)境生物化學(xué)與分子毒理學(xué)（研）, 講課 , 北京大學(xué) , 春季學(xué)期

已畢業(yè)研究生
2011級(jí)碩士研究生，胡瑩，深圳大學(xué)化學(xué)與環(huán)境工程學(xué)院

2012級(jí)碩士研究生，孫利北，河北省選調(diào)

2013級(jí)碩士研究生，周與茵，出國(guó)深造

2014 級(jí)碩士研究生，郭記龍，出國(guó)深造

2015 級(jí)碩士研究生，余彤，出國(guó)深造

2016級(jí)碩士研究生，范曉琳，轉(zhuǎn)博

2017級(jí)碩士研究生，肖寒，工作

在校研究生

楊磊

郭旋

毛興臺(tái)

...

博士后

賈曉靜